The Effect of Renal Hemodialysis on Serum Endogenous Antioxidants Defense of Patient with Chronic Renal Failure

Abstract

Hemodialysis means removes waste and excess fluid from the blood when thekidneyscannot do so sufficiently usually performed three or more times a week for 4 hours or more.The present work was aimed to investigate the effect of renal hemodialysis on serum anenzymatic and non-enzymatic endogenousantioxidantsdefenses. Forty five patientswere taken for this study, 25males (55.54%) with age range (11-70) years and 20 females (44.46%) with age range (6-65)years, while the subjects of control group was thirty five individuals non-undergoing hemodialysis treatment, 23 males (65.71%) with age range (15-65) years and 12 females (34.29%) with age range (18-62) years. The present results showed highly significantly decrease (p<0.05) in serum enzymatic endogenous antioxidant (catalase) andnon-enzymatic antioxidants (transferrin and bilirubin), while serum non enzymatic antioxidant uric acid showed highly increase (p<0.05) in patient with chronic renal failure.In conclusion, the present data showed that patients with chronic renal failure (CRF) undergoing hemodialysis treatmenthave physiological disturbances in both serum enzymatic and non-enzymaticendogenous antioxidants levels in all age ranges may be related to oxidative stress by renal failure disease.