Effect of high-fructose corn syrup on some obesity markers in adult male rats

Abstract

High-fructose corn syrup (HFCS) accounts for as much as 40% of sweeteners used over all the world as an industrial sweetener - a substitute for sugar. As obesity has increase rapidly to epidemic proportions around the world, adipose derived hormone play central role in regulation of appetite , balancing between calorie input and calorie expenditure , so the current experiment conducted to investigate the effect of HFCS on serum adiponectin , leptin , resistin hormone levels, lipid profile , body weights , food intake , and relative abdominal fat as obesity markers in adult male rats . Thirty adult male rats weighing 200 -225 gram and 12 – 15 weeks old were randomly divided in to five equal groups. The first group (Groups A) was given a 10% solution of HFCS, the second group (Groups B) was given a 20% solution of HFCS ,the third group ( group C ) was given a 10% solution of sucrose , the fourth group ( group D ) was given a 20% solution of sucrose , the fifth group ( group E ) was given a distilled water for thirty days . All groups were fed with standard rat diet and their solutions ad libitum. At the end of experiment the animals were weighted, sacrificed, blood samples were collected by heart puncture . There were a significant increase (p ≤ 0.05 ) in body weights , relative abdominal fat , serum TC , TAG , LDL-c , and VLDL-c , leptin hormone , and resistin hormone in group B compared with all groups of experiment . There were a significant increase in body weights , relative abdominal fat , serum TC , TAG , LDL-c , and VLDL-c , leptin hormone , and resistin hormone in groups A , C and D compared with group E ,whereas there were no significant differences between group A and groups C, D in all studied parameters when compared with each other’s. Serum HDL-c and adiponectin hormone decreased in groups A, B, C, D when compared with group E. There were no significant differences in HDL-c and adiponectin hormone in groups A, B, C, and D when compared with each other’s. In Conclusions excessive consumption of HFCS may contribute to the incidence obesity and dyslipidemia.