Cytotoxicity impacts of Omnipaque 350 and X-ray on mice chromosomales

Abstract

n this paper, the percentage of chromosomal aberrations, micronuclei and mitotic index were measured in mice bone marrow as a method for assessing the ability of Omnipaque 350 to increase chromosomal aberrations, micronuclei and reduce mitotic index with or without X-ray. Laboratory mice were used for this purpose and divided into two groups: control groups and treated groups. Control groups consist of three groups, two are negative groups (the first received 0.25 ml of distilled water and the second was irradiated by three doses of 60 KeV) while the last one is positive group which was treated with 0.25ml of Omnipaque only for 24 hour. The treated groups are treated with Omnipaque and X-ray together but in different times by injection Omnipaque before, after and between two radiations. Experimental data was analyzed. The results demonstrated that Omnipaque alone has the ability to increase chromosomal aberrations, micronucleus and reduce mitotic index significantly (P<0.05).