Clinicopathological association of Uterine Fibroids with SOX4 gene overexpression

Abstract

Uterine fibroids represent the major public problem and the commonest benign tumors. This study.was intended to determine the role of SOX4 gene in induction uterine fibroids, for these purpose 25 patients aged 37-70 years with severe uterine bleeding followed hysterectomy were included in this study. Histopathological of biopsies findings confirm the incidence of uterine fibroids. According the body mass index, the SOX4 gene expression recorded a high significant increase (p> 0.01) :Normal weight =1.74, Overweight =2.94 and Obese=3.81 when compared to control group that recorded in Normal weight =1.08, Overweight =1.04 and Obese=1.04 respectively. On the other hand; the effect of age in SOX4 gene expression folding revealed there was a highly significant increase on (p> 0.01) in group aged less than 45 years (2.6209) when compared to control group (1.0769). In more than 45 years mean folding of SOX4 gene recorded (3.443) when compared to control group (1.020).