The Effect of Interleukin-37 Plasma Levels and SNP il-37 Gene in Ulcerative Colitis in Iraqi Patient’s

Abstract

Ulcerative colitis (UC) is a chronic inflammation of the gastrointestinal tract without any signs of infection. The association between genetic variations in the IL-37 gene and increase in serum IL-37 levels in UC has not been investigated. The aim of study was found the association between IL-37 genetic variants, IL-37 plasma levels, and various clinical phases of UC. Serum concentrations of IL-37 in UC reveled (56.72± 16.41) using ELISA, and genetic variants were genotyped by (PCR) and the sanger sequence technique. It was found that the G>A genotype of (rs3801147) occurs significantly more frequently in patients with active UC. Since the allele G is considered a common allele in patients, it may have a good etiological role for disease.