A study of some antibiotics and NaCl affecting Serratia marcescens growth and product prodigiosin pigment

Abstract

Serratia marcescens is a bacteria which is sensitive to some antibiotics(trimethoprime, Ciprofloxacin, Cefotaxime, Cephoxitin, Neomycin, Gentamycin, Nalidixic acid, Amikacin) and the Ciprofloxacin has higher capability to inhibit its growth, but it is resistante to(Augmentin, Erythromycin, Cephalothin, Clarithomycin, Tetracycline, Vancomycin, Ampicillin) ,and it produces B-lactamases .
The prodigiosin is a pigment that is produced from S. marcescens and may be defense agent against antibiotics so it increases its production with 85.71%, from antibiotics that affect bacteria growth, while it is not produced with (Tetracycline، Cephoxitin، Clarithomycin ) , while, Ampicillin، Vancomycin، Cephalothin، Erythromycin don’t affect bacteria growth and pigment production .
The components media such as NaCl affect S. marcescens growth and pigment production, the growth decrease gradually at2% concentration and stop growth at 10% concentration to both period (24-48) hr.,while the pigment shows high product at 2% concentration and then decreases gradually to stop at 10% concen.to both period (24-48) hr.