Effect of Carbamazepine (Tegretol) on Some Functional Testicular Parameters in Adult Male Mice

Abstract

Carbamazepine as a drug used in the treatment of epilepsy and neuropathic pain has been shown to cause reproductive disorders. The present study was aimed to determine the effects of different doses of Carbamazepine (CBZ) (Tegretol) on the sex hormones and some testes parameters of adult albino Swiss mice. The study sample included 24 male mice divided into 4 groups. 1^st, 2^nd and 3^rd groups were orally administrated with a daily dose 2.5, 5 and 10 mg/kg bw carbamazepine respectively. While group four served as control and administrated with 0.1 mL distilled water for 60 days. The present study investigates effects of carbamazepine medication on serum sex hormones (folicall stimulating hormone FSH, prolactin hormone, lutinizing hormone LH and testosterone hormone) as well as sperm functional parameters. It can be concluded that acute exposure to carbamazepine exerts negative effects on testes parameters of treated mice.