EFFECT OF HALOPERIDOL ON SELECTED OXIDATIVE STRESS PARAMETERS AND DOPAMINE LEVEL IN RATS BRAIN

Abstract

The present study was conducted to assess the effects of haloperidol (psychiatric drug ) on some oxidative stress parameters (GSH and lipid peroxidation product MDA) and it's relation to the dopamine level in rats' brain.
Twenty-four male Sprague- Dawely rats were enrolled in this study. They were randomly separated into three groups, eight rats in each group: Group 1, (normal control group), eight rats were put on normal chow diet for 45 days from which the baseline value of selected parameters were measured. Group 2 (self control group) on distilled water orally administered by stomach tube for 45 days. Group 3 on Haloperidol 1 mg/kg orally administered by stomach tube for 45 days.
After decapitation, brain were removed from rats and homogenized from which GSH, MDA, and dopamine levels were measured. This study revealed the following results.
1- Administration of haloperidol was highly significant (P value < 0.01) decreased the GSH and dopamine level in rats' brain.
2- Administration of haloperidol was highly significant (P value < 0.01) increased the MDA levels in rats' brain.
It was concluded that haloperidol is a potent inducer of oxidative stress and highly decreased the levels of dopamine in rats' brain.