The effect of experimentally induced hyperglycemia by alloxan on some hematological parameters in rabbits

Abstract

The study was designed to investigate the effects of hyperglycemia on some hematological and serum lipid parameters in rabbits during a period of seventy days. This study was achieved in the university of Al-Qadisyiah / college of veterinary medicine college department of pathology from 31/10/2008 till 10/02/2009. The parameters evaluated include serum lipids, red and white blood cell indices. The results show that the hyperglycemia significantly reduced (P<0.05) packed cell volume and red blood cell count when compared with control groups. Also, the hyperglycemia significantly reduced (P<0.05) white blood cell count when compared with control. Moreover, the hyperglycemia significantly elevated (P<0.05) total cholesterol concentration in the serum while it had less significant effect (P<0.05) on serum HDL-cholesterol concentration when compared with controls. Whereas, hyperglycemia significantly increased (P<0.05) serum triglycerol concentration. The results of this study suggest that hyperglycemia may have extrusive effect on serum cholesterol concentration, although it possibly possesses the potential of adversely affecting some hematological indices.