Predicting Role of VKORC1 Gene and Cardiac Enzymes in Incidence of Cardiovascular Diseases

Abstract

VKORC1 gene encodes the VKORC1 enzyme that resides in endoplasmic reticulum membrane, and responsible for activating and recycling of vitamin K. The current study investigates the frequency of VKORC1 gene polymorphism in patients with cardiovascular diseases, and relationship with levels of serum cardiac enzymes in Wasit province (Iraq). Genetic analysis shows the significant high frequency of VKORC1-1639G >A was seen among the GA genotype (48.33%) when compared to GG (38.33%) and AA (13.33%) genotypes. While significant reduction was reported in GA genotype (8.33%) in comparison with other GG (63.33%) and AA (20%) genotypes in healthy cases. Subsequently, the frequency of G allele in patient and healthy individuals was significantly higher than the frequency of A allele. Regarding cardiac enzymes. This study demonstrates the effect of VKORC1-1639G>A polymorphism on incidence of cardiovascular diseases as shown in increasing the frequency of GA genotype in study patients compared to healthy individuals.