Histopathological effects of the prednisolone and vitamin E in the different organs (liver, lung, heart and testis) of the rabbits

Abstract

The aim of this study was to investigate the histopathological effects of prednisolone and vitamin E on the different organs of the different system in the experimental animal.
Materials and methods: histopathological study was carried out in 21 days, using a hematoxylin- eosin method, twenty adult males rabbits were randomly divided into four groups: Grop-1: control group C. (n = 5) received Distilled water 4 ml /kg b.w./day/orally
Group-2: first treated T1. (n=5) with 4mg/kg b.w/day/orally prednisolone.
Group-3: second treated T2.(n=5) with 400 IU/kg b.w/day/orally/ vitamin E.
Group-4: third treated T3. (n=5) with prednisolone and vitamin E orally. At day 22th, the animals were sacrificed and samples from Heart, liver, lung and testis). were obtained for Histopathological study.
Results: the results showed that vitamin E appeared to ameliorate the adverse effects of prednisolone on the histopathological picture of the different organs.
Conclusion: vitamin E is effective in reducing damage in prednisolone – Treated rabbits.