Antibacterial and anti-inflammatory activity of sesquiterpene lactones compounds extracted from Artemisia Herba Alba plan

Abstract

The Artemisia Herba Alba plant, is widespread in Iraq and its municipal kind called Artemisia herba alba is used as anti-parasites and anti-bacterial agent, it also has effective against different kinds of infections, this activity returns to Sesquiterpene lactone compounds, which are the main product of the Artemisia Herba Alba oil. In this study, these compounds were extracted from the Artemisia Herba Alb plant. The effectiveness of five one-half concentrations (200,100,50,25,12.5) mg / ml, against five species of pathogenic bacterial isolates from urinary tract infections (UTI) cases were tested , The activity of Sesquiterpene lactone compounds was significant (P<0.05) for highest concentration of 200 mg /ml against P. aeruginosa, while the activity was not significantly against K .pneumoniae ,S. pneumoniae ,S. pyogenes when it is compared with standard antibiotic which is used against these pathogenic bacteria. In this study the anti-inflammatory activity of Sesquiterpene lactone compounds which induced by injection of carrageenan at the feet of laboratory mice, we found that these compounds was significantly (P <0.05) more active in reducing the inflammation caused by the injection of carrageenan but not those efficiency shown by the use of anti-inflammatory aspirin to reduce inflammation to the laboratory mice resulting from the injection of carrageenan.