Ion-pair extractive spectrophotometric determination of isopropamide iodide in pharmaceutical formulations and environmental wastewater samples using Bromo phenol blue

Abstract

A simple, accurate and sensitive spectrophotometric method was developed for the determination of isopropamide iodide in pharmaceutical formulations and environmental wastewater samples. The method was based on the formation of ion-pair between isopropamide iodide and bromophenol blue (BPB). The colored product was extracted into chloroform and measured spectrophotometrically at 600 nm. Beer’s law was obeyed in the concentration range of 2.0-20.0 μg/mL with molar absorptivity and Sandell’s sensitivity of 3.17 × 104 L /mol. cm and 15.15 ng/.cm2 respectively. The relative standard deviation (RSD) is better than 1.5. The method was applied successfully to the determination of isopropamide iodide in environmental wastewater samples and in pharmaceutical formulations (tablets).