The protective role of clomiphene citrate against the hormonal disturbances caused by atrazine exposure in adult male rats

Abstract

The present study aimed to investigate the protective role of clomiphene citrate against the hormonal disrubances caused by atrazine exposure. Thirty adult male rats were used, they divided randomly and equally into five groups. The first group serve as a control group orally dosed with distilled water , the rest four groups orally dosed with :- atrazine (ATZ) 50 mg /kg b.w. , ATZ 50 mg /kg b.w, and clomiphene citrate (CC) 0.5 mg / kg b.w. , ATZ 50 mg /kg b.w. and CC 0.6 mg / kg b.w. , ATZ 50 mg /kg and CC 0.7 mg / kg b.w. daily for 30 days. The results showed that atrazine exposure result in significant decrease (p≤ 0.05) in serum testosterone, FSH, LH, and adiponectin hormones in atrazine exposed group compared with control group . The protective treatment with 0.6 and 0.7 mg / kg b.w of CC result in significant increase (p≤ 0.05) in serum testosterone, FSH , LH , and adiponectin hormones compared with atrazine exposed group . The response to the dose of 0.5 mg / kg b.w. of CC result in significant increase in serum levels of LH , and adiponectin hormones and non-significantly different from atrazine exposed group in FSH and testosterone serum level . It has been concluded from the present study that clomiphene citrate have a positive effects on serum level of testosterone, FSH , LH , and adiponectin hormones.