Effect of origanum vulgare extract on glucose level and some parameters of immunity in alloxane diabetic mice

Abstract

It is aimed to study effects of origanum vulgare on serum glucose, blood film (total and differential white blood cells and immunoglobulin (IgG,IgM,IgA and complements C3 , C4) in alloxane-induced diabetic mice. Animals were divided into five groups of 5 animals each as follows: Non-diabetic mice (control group), non-treated alloxane diabetic mice, alloxane diabetic mice treated with origanum vulgare. Alloxan diabetic mice were injected with Origanum Vulgare extract for 1,2,3 weeks at a dosage of 0.18 g/kg body weight. The mice treated with alloxan (150 mg/kg B.W) to induce diabetic were showed increased in blood glucose level (hyperglycemia) , decreased in total and differential WBCs and immunoglobulin (IgG,IgM,IgA and complements C3 , C4) compared with control group, while the results of alloxan diabetic mice treated with origanum vulgare showed significantly (P<0.05) decreased in blood glucose level , increased in total and differential WBCs and immunoglobulin (IgG,IgM,IgA and complements C3 , C4) compared with alloxan diabetic mice group with out treated.